Roy Aaron, MD

Publications

• Chen, Y., R. Pareta, B. Bilgen, A. Myles, H. Fenniri, D. McK. Ciombor, R.K. Aaron, T. Webster. Self-assembled rosette nanotube/hydrogel composites for cartilage tissue engineering. Tissue Eng Part C Methods. In Press.
• Puckett, S., P.P. Lee, D. McK. Ciombor, R.K. Aaron, T. Webster. Nanotextured titanium surfaces for enhancing skin growth on transcutaneous osseointegrated devices. Acta Biomaterialia. 6: 2352-62; 2010.
• Gerin-Lajoie, M., D. McK. Ciombor, W. Warren, R.K. Aaron.  Using ambulatory virtual environments for the assessment of functional gait impairment: A proof-of-concept study. Gait and Posture. 31: 533-536; 2010.
• Dyke, J.P., R.K. Aaron.  Non-invasive methods of measuring bone blood perfusion.  Ann. NY Acad. Sci.1192:95-102; 2010.
• Bilgen B, Y. Ren, M. Pei, R.K. Aaron, D. McK. Ciombor. CD14-Negative isolation enhances chondrogenesis in synovial fibroblasts.  Tissue Eng.  15: 3261-3270; 2009.
• Lee, J.H., J. Dyke, D. Ballon, D. McK. Ciombor, M. Rosenwasser, R.K. Aaron. Subchondral fluid dynamics in a model of osteoarthritis: Use of dynamic contrast-enhanced magnetic resonance imaging. Osteoarthritis and Cartilage.  17: 1350-1355; 2009.
• Lee, J.H., J. Dyke, D. Ballon, D. McK. Ciombor, G. Tung, R.K. Aaron. Assessment of bone perfusion with contrast-enhanced magnetic resonance imaging. Ortho Clin N Am. 40: 249-257; 2009.
• Covey, D. C. Born, R.K. Aaron, D. McK. Ciombor, et. al. Orthopaedic war injuries:  Recent developments in treatments and research. AAOS Instructional Course Lectures. 58: 117-129; 2009.
• Ciombor, D. McK., R.K. Aaron. Electric, electromagnetic, and acoustic treatment for avascular necrosis of the femoral head. Techniques in Orthopaedics. 23: 11-17; 2008.
• Jaklenec A, A. Hinckfuss, B. Bilgen, D. McK. Ciombor, R.K. Aaron, E. Mathiowitz. Sequential release of bioactive IGF-I and TGF-?1 from PLGA microsphere-based scaffolds. Biomaterials.10:1518-25; 2008.
• Covey, D. R.K. Aaron, C. Born, J. Calhoun, T. Einhorn, H. Frisch, L. Levin, M. Mazurek, E. Schwartz, J. Wenke, E. Powell. Orthopaedic war injuries from combat casualty care to definitive treatment: a current review of the basic science, clinical advances and research opportunities. AAOS Instructional Course Lectures. 57: 65; 2008.
• Bilgen B, E. Orsini, R.K. Aaron, D. McK. Ciombor. FBS suppresses TGF-?1-induced chondrogenesis in synoviocyte pellet cultures while dexamethasone and dynamic stimuli are beneficial. J. Tissue Eng. Regen. M., 1: 436 – 442; 2007.
• Aaron, R.K., J. Dyke, D. McK. Ciombor, D. Ballon, J. Lee, E. Jung, G. Tung. Perfusion abnormalities in subchondral bone association with marrow edema, osteoarthritis and avascular necrosis. Ann. NY Acad. Sci. 1117: 124-137; 2007.
• Aaron, R.K., D. McK. Ciombor, M. Lysaght, E. Mathiowitz, M. Ehrlich Regenerative medicine for limb trauma. Medicine and Health/Rhode Island. 90: 6; 2007.
• Aaron, R.K. and J. Morgan. Biohybrid limbs: New materials and new properties Medicine and Health/Rhode Island. 90: 4; 2007.
• Aaron, R.K. and R. Gray. Osteonecrosis: Etiology, Natural History, Pathophysiology and Diagnosis. In: The Adult Hip, 2nd edition. Eds: J. Callaghan, A. Rosenberg, and H. Rubash. Lippincott Williams & Wilkins, Philadelphia, PA. v. 1 pg 463-476; 2007.  
• Aaron, R.K. and D. McK. Ciombor. Orthopaedic complications of solid organ transplantation. Surg. Clin. N Am. 86: 1237-1255; 2006.
• Aaron, R.K., H. Herr, D. McK. Ciombor, L. Hochberg, J. Donoghue, C. Briant, J. Morgan, M. Ehrlich. Horizons in prosthetic development for restoration of limb function. J. Am. Acad. Orthop. Surg. 14: S198-204: 2006.
• Paek, H.J., A.B. Campaner, J.L. Kem, L. Golden, R.K. Aaron, D. McK. Ciombor, J. Morgan, M. Lysaght. Microencapsulated cells genetically modified to overexpress human transforming growth factor-beta1: viability and functionality in allogeneic and xenogeneic implant models. Tissue Eng. 12: 1733-9; 2006.
• Ciombor, D. McK., A Jaklenec, A. Liu, C. Thanos, N. Rahman, P. Weston, R. Aaron, E. Mathiowitz. Encapsulation of BSA using a W/O/O emulsion solvent removal method. J. Microencap. 23: 183-194; 2006.
• Aaron, R.K., D. McK. Ciombor, S. Wang. Clinical biophysics: The promotion of skeletal repair by physical forces. Ann. N.Y. Acad. Sci. 1068: 513-531; 2006.
• Aaron, R.K., A. Skolnick, S. Reinert, D. McK. Ciombor. Arthroscopic debridement for osteoarthritis of the knee. J. Bone Joint Surg. 88A: 936-943; 2006.
• Aaron, R.K., E. Bluman, M.G. Ehrlich, P.G. Trafton.  The Pelvis, Hip and Thigh. In: Netter Textbook of Orthopaedics.  Ed:  W. Greene. p. 363-394, Elsevier Saunders, Philadelphia, PA. 2006.
• Ciombor, D. McK. and R.K. Aaron. The role of electrical stimulation in bone repair.  Foot and Ankle Clinics. 10: 579- 593; 2005.
• Paek, H.J., A.B. Campaner, J.L. Kim, R.K. Aaron, D. Ciombor, J. Morgan, M. Lysaght. In-vitro characterization of TGF-?1 release from genetically modified fibroblasts in calcium alginate microcapsules. ASAIO. 51: 379-384, 2005.
• Aaron, R.K. and M. Bolander (eds.). Physical Regulation of Skeletal Repair. American Academy of Orthopaedic Surgeons, Chicago, IL. 2005.
• Aaron, R.K., and D. McK. Ciombor. Pain in osteoarthritis. Medicine and Health/RI. 87: 205-209; 2004.
• Aaron, R.K., B. Boyan, D. McK. Ciombor, Z. Schwartz, B. Simon. Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop Relat. Res. 419: 30-37; 2004.
• Aaron, R.K., D. McK. Ciombor, B. Simon. Treatment of nonunions with electric and electromagnetic fields. Clin Orthop. Relat. Res. 419: 21-29; 2004.
• Shalvoy, R., G. Ferguson, R.K. Aaron. Hip and Knee Pain. In: Primary Care for Women. Eds: P. Leppert and J. Peipert. p. 652-658, Lippincott-Raven, Philadelphia, PA. 2003.
• Ciombor, D. McK., R.K. Aaron, S. Wang, and B. Simon.  Modification of osteoarthritis in the guinea pig – A morphological study.  Osteoarthritis and Cartilage. 11: 455-462; 2003.
• Lieberman, J., D. Berry, M. Mont, R.K. Aaron, et al. Osteonecrosis of the hip: Management in the 21st century. AAOS Instructional Course Lectures. 52:337; 2003.
• Lieberman, J., D. Berry, M. Mont, R.K. Aaron, et al.  Osteonecrosis of the hip: Management in the 21st century. J. Bone Joint Surg. 84: 834-853; 2002.
• Aaron, R.K., S. Wang, and D. McK. Ciombor.    Upregulation of basal TGF-b levels coincident with chondrogenesis. Implications for skeletal repair and tissue engineering. J. Orthop. Res.  20:  233-240; 2002.
• Ciombor, D. McK., G. Lester, R.K. Aaron, P. Neame, and B.  Caterson.  Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins J. Orthop. Res. 20: 40-49; 2002.
• Aaron, R.K. and D. McK. Ciombor. Coagulopathies in osteonecrosis. Curr. Opin. Ortho. 12: 378-383; 2001.
• Aaron, R.K.  Concepts of the pathogenesis of osteonecrosis. Techniques in Orthopaedics 16: 101-104; 2001.
• Aaron, R.K.  Technique of core decompression.  Techniques in Orthopaedics 16: 98-100; 2001.
• Ciombor, D. McK. and R.K. Aaron.  Biologically augmented core decompression for the treatment of osteonecrosis of the femoral head. Techniques in Orthopaedics 16: 32-38; 2001.
• Aaron, R.K., B. Stulberg and D. Lennox.  Clinical and radiographic outcomes in untreated symptomatic osteonecrosis of the femoral head.  Techniques in Orthopaedics 16: 1-5; 2001.
• Collaborative Osteonecrosis Group.  Multifocal osteonecrosis - A multicenter study.  Clin. Orthop. Relat. Res.  369: 312-326; 1999.
• Aaron, R.K. and D. McK. Ciombor.  Preservation of the hip in osteonecrosis of the femoral head.  In:  Modulazione Biofisica Della Osteogenesi Mediante Campi Elettromagnetici Pulsati. Vol. II; Eds. G.C. Traina, F. Pipino, L. Massari, L. Molfetta, and R. Cadossi. p. 69-74.  Walberti Editore, Ravenna, Italy1999.
• Ciombor, D. McK. and R.K. Aaron.  EMF stimulates cartilage differentiation in endochondral ossification coincident with an increase in TGF-b expression. In:  Electricity and Magnetism in Biology and Medicine.  Ed; F. Bersani p. 139-144.  Kluwer Academic/Plenum Publishers, New York, NY, 1999.
• Aaron, R.K., D. McK. Ciombor, H. Keeping, et al.  Power frequency fields promote cell differentiation coincident with an increase in TGF-b expression.  Bioelectromagnetics.20: 453-458, 1999.
• Aaron, R.K. and D. McK. Ciombor.  Electrical stimulation, demineralized bone matrix, and bone morphogenic protein. Semin. Arthroplasty.  9:221-30, 1998.
• Carson, J.L., M.L. Terrin, F.B. Barton, R.K. Aaron, A.G. Greenberg, et al.  A pilot randomized trial comparing symptomatic vs. hemoglobin-level-driven red blood cell transfusions following hip fracture.  Transfusion. 38:522-29, 1998.
• Scully, S., R.K. Aaron and J. Urbaniak.  Survival analysis of hips treated with core decompression or vascularized fibular grafting because of avascular necrosis.  J. Bone Joint Surg. Am.  80:1270, 1998.
• Aaron, R.K., D. McK. Ciombor and C. Polk.  Therapeutic potential of electric fields in skeletal morphogenesis.  In: Skeletal Growth and Development:  Clinical Issues and Basic Science Advances.  Eds.  J.A. Buckwalter, M.G. Ehrlich, L.J. Sandell, and S.B. Trippel. p. 589-610, AAOS, Chicago, IL. 1998.
• Aaron, R.K. Musculoskeletal disease (Editorial).  Medicine and Health/Rhode Island. 81:154, 1998.
• Aaron, R.K.  Importance of the early diagnosis of hip pain: New approaches to hip preservation in osteonecrosis.  Medicine and Health/Rhode Island 81:157, 1998.
• Polk, C., R.K. Aaron, and D. McK. Ciombor. Therapeutic applications of low frequency electric and magnetic fields in the US. In: Treatment with Electromagnetic Fields. Ed: J.P. Stossel. Schattauer, Stuttgart, Germany. 1997.
• Aaron, R.K., D. McK. Ciombor, and C.F. Lord.  Core decompression augmented with human decalcified bone matrix graft for osteonecrosis of the femoral head.  In:  The Etiology, Diagnosis and Management of Osteonecrosis of the Human Skeleton. Ed. J. Urbaniak. p. 301, AAOS, Chicago, IL. 1997.
• Aaron, R.K., D. Lennox and B. Stulberg.  The natural history of osteonecrosis of the femoral head and risk factors for progression.  In: The Etiology, Diagnosis and Management of Osteonecrosis of the Human Skeleton. Ed. J. Urbaniak. p. 261, AAOS, Chicago, IL. 1997.
• Aaron, R.K.  Osteonecrosis:  Etiology, pathophysiology and diagnosis.  In:    The Adult Hip. Eds:  J. Callaghan, A. Rosenberg, and H. Rubash. p. 451, Raven Press, New York, NY. 1997.
• Aaron, R.K., and D. McK. Ciombor. The role of electrical stimulation in the treatment of avascular necrosis of the femoral head. Curr. Orthopaed. London, UK. 11:187, 1997.
• Aaron, R.K. and D. McK. Ciombor.  Acceleration of experimental endochondral ossification by biophysical stimulation of the progenitor cell pool.  J. Ortho. Res. 14: 582-589, 1996.
• Aaron, R.K. Treatment of osteonecrosis of the femoral head with electrical stimulation In: Impiego Dei Campi Elettromagnetici Pulsati (CEMP) in Orthopedia E Traumatologia.  Eds. G.C. Traina, L. Romanini, L. Massari, C. Villani, and R. Cadossi.  P.69, Walberti Ediore, Ravenna, Italy.  1995.
• Aaron, R.K. Treatment of osteonecrosis of the femoral head with electrical stimulation.  AAOS Instructional Course Lectures  43:495, 1994.
• Aaron, R.K. Advances in the surgical treatment of arthritis. R.I. Med. J. 77:16,1994.
• Aaron, R.K. and D. McK. Ciombor.  Therapeutic effects of electromagnetic fields in the stimulation of connective tissue repair.  J. Cell. Biochem. 52:42-46, 1993.
• Ciombor, D. McK. and R.K. Aaron.  Influence of electromagnetic fields on endochondral bone formation.  J. Cell. Biochem.  52:37-41, 1993.
• Gershuni, D., R.K. Aaron, C.T. Brighton, F. Magee, and C.F. Smith. Symposium-Recent Advances in Electrical Stimulation.  Contemp. Ortho. 26:609, 1993.
• Aaron, R.K. and D. McK. Ciombor.  Electrical stimulation of bone induction and bone grafting.  In: Bone Grafts and Bone Substitutes. Ed.: M. Habal and A.H. Reddi.  p. 192, W.B. Saunders Inc, Philadelphia, PA. 1992.
• Aaron, R.K. and M.E. Steinberg.  Electrical stimulation of osteonecrosis of the femoral head.  Semin. Arthroplasty. 2:214, 1991.
• Aaron, R. K., D. Lennox, G. Bunce, D. McK. Ciombor, and T. Ebert.  Durability of outcome in osteonecrosis of the femoral head treated with pulsing electromagnetic fields or core decompression.  In: Electromagnetics in Medicine and Biology. Ed: C.T. Brighton and S.R. Pollack. p.309, San Francisco Press, San Francisco, CA.1991.
• Savin, H. B., Zimmermann, R.K. Aaron, P. Libbey, J. Alper, and E.V. Lally. Seronegative symmetric polyarthritis in Sezary syndrome. J. Rheumatol. 18:464, 1991.
• Aaron, R.K. Basic science of fractures and fracture healing. Curr. Opin. Ortho.  1:294, 1990.
• Aaron, R.K., D. Lennox, G.E. Bunce and T. Ebert.  The conservative treatment of osteonecrosis of the femoral head - A comparison of pulsed electromagnetic fields and core decompression. Seventeenth Open Meeting of the Hip Society.  Clin. Orthop. Relat. Res. 249:209, 1989.
• Froehlich, J., G.S. Dorfman, J. Cronan, P.J. Urbanek, J.H. Herndon, and R.K. Aaron. Compression ultrasound for detection of deep venous thrombosis in patients with hip fractures: A prospective study.  J. Bone Joint Surg. Am.  71A:249, 1989.
• Aaron, R.K., D. McK. Ciombor and G. Jolly. Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields.  J. Bone Miner. Res. 4:227-233, 1989.
• Aaron, R.K., G. Jolly, D. McK. Ciombor, and H-J. Barrach.  A histochemical method for the demonstration of calcifying cartilage.  Calcified Tissue Int. 43:244, 1988.
• Limbird, R.S. and R.K. Aaron.  Laterally comminuted fracture dislocations of the ankle.  J. Bone Joint Surg. Am.  69A:881, 1987.
• Aaron, R.K. Patients at risk for femoral osteonecrosis. Diagnosis 9:51, 1987.
• Aaron, R.K., C.B. Sledge, and S. Shortkroff.  Experimental arthritis induced by polysaccharide macromolecules.  Arthritis Rheum. 30:679, 1987.
• Aaron, R.K. and R. Scott.  Supracondylar fractures after total knee replacement.  Clin Orthop Relat Res. 219:30, 1987.
• Aaron, R.K. and D. McK. Ciombor.  Treatment of osteonecrosis of the femoral head with pulsed external magnetic fields. Ann. N.Y. Acad. Sci. 435:367, 1985.
• Aaron, R.K., D. McK. Ciombor, R. Glasser and S. Bruder.  Quantitative histomorphometric analysis of decalcified bone matrix-induced enchondral ossification.  Ann. N.Y. Acad. Sci.  435:237, 1985.
• Aaron, R.K. and D. McK. Ciombor.  Venous thromboembolism in orthopaedic surgery.  Surg.Clin. N Am. 63:529, 1983.
• Aaron, R.K. Total joint arthroplasty. Surg. Clin. N Am. 63:697, 1983.
• Brook, I. and R.K. Aaron.  Hospital-based aspergillus flavus infection in a surgical wound:  A case report.  Orthopaedics 3:1215, 1980.
• Aaron, R.K., L. Ellman, A. Carvalho and W.H. Harris.  Relationship of intravascular coagulation and fibrinolysis to venous thrombosis following total hip replacement.  Clin Orthop Relat Res. 135:148, 1978.
• Aaron, R.K.  Reduction of Hageman factor, prekallikrein, and kininogen in surgical stress.  In:  The Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease.  Eds.:  J.J. Pisano and K.F. Austen.  P. 545.  National Institutes of Health, DHEW 76-791, 1976.
• Aaron, R.K., R. Beazley and G. Riggle.  Hematologic integrity after intraoperative autotransfusion - a comparison with bank blood.  Arch. Surg.  108:831, 1974.
• Aaron, R.K., S. Srinivasan and P.N. Sawyer.  Synthetics and Implants. In:  Medical Engineering. Ed: C. D. Ray.  Year Book Medical Publishers, Chicago, Illinois. 1973.
• Roberts, A.J., R.K. Aaron, D. Conkle, J. Brown, E. Stinson and C. McIntosh.  Lasix and albumin therapy in the post-operative cardiac patient.  Circulation 48 (Suppl):207, 1973.
• Bennett, S., G. Geelhoed, R.K. Aaron, T. Solis and R. Hoye.  Pulmonary injury resulting from perfusion with stored bank blood in the baboon and the dog. J. Surg. Res. 13:295, 1972.
• Aaron, R.K., S. Srinivasan, D. Burrowes, and P.N. Sawyer.  Effects of chemical compounds upon current-induced thrombosis in rat mesenteric vessels.  Thromb. et Diath. Haemorr. 23:621, 1970.
• Aaron, R.K., T. Lucas, S. Srinivasan and P.N. Sawyer.  Alterations in vascular surface charge and propensity to thrombosis produced by blood vessel injury. Bull. N.Y. Acad. Med. 45:969, 1969.
• Srinivasan, S., R.K. Aaron, P. Chopra, T. Lucas and P.N. Sawyer.  Effects of thrombotic and anti-thrombotic drugs on surface charge characteristics of canine blood vessels in vivo and in vitro.  Surgery. 64:827, 1968.